The analgesic activity of morphine-6-glucuronide.
نویسندگان
چکیده
منابع مشابه
Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers.
The pharmacodynamics of morphine-6-glucuronide (M-6-G) i.v. were assessed in 12 healthy male volunteers in an open study. After a single bolus dose of M-6-G 5 mg i.v., we measured antinociceptive effects, using electrical and cold pain tests, and plasma concentrations of M-6-G, morphine-3-glucuronide (M-3-G) and morphine. Pain intensities during electrical stimulation (at 30, 60 and 90 min afte...
متن کاملRelative contribution of morphine and morphine-6-glucuronide to the analgesic effect after morphine administration.
Editor—We thank Dahan and Lotsch for their interest in our review and their valuable comments to the discussion about the role of morphine-6glucuronide (M6G), for the analgesic effect after morphine administration. Because morphine is used worldwide as the potent standard analgesic drug, with the formation of an even more potent metaboliteM6G, it is important to elucidate the relative contribut...
متن کاملInfluence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide
INTRODUCTION Obesity is associated with many pathophysiological changes that may result in altered drug metabolism. The aim of this study is to investigate the influence of obesity on the pharmacokinetics of morphine, morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G) through a combined analysis in morbidly obese patients and non-obese healthy volunteers. METHODS In this analysis,...
متن کاملPharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients
BACKGROUND AND OBJECTIVE Morphine dosing can be challenging in terminally ill adult patients due to the heterogeneous nature of the population and the difficulty of accurately assessing pain during sedation. To determine the pharmacokinetics of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) in this population, and to find clinically relevant parameters for dose individu...
متن کاملMorphine, morphine-3-glucuronide, morphine-6-glucuronide, and 6-monoacetylmorphine determined by means of atmospheric pressure chemical ionization-mass spectrometry-liquid chromatography in body fluids of heroin victims.
Morphine, morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G), and 6-monoacetylmorphine (6-MAM) were isolated from body fluids using solid-phase extraction and determined by means of atmospheric pressure chemical ionization-mass spectrometry-liquid chromatography (APCI-LC-MS) in selected ion monitoring mode. The following ions were monitored: m/z 286 for morphine; m/z 286 and 462 for M3G...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1992
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1992.tb04121.x